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EFFECT OF CLEARANCE AND VOLUME OF DISTRIBUTION ON HALF-LIFE

   0.5 X

    0.5 X

2.0 X

2.0 X

case

example

Clearance:

Volume of distribution:

The Elimination Half-life is a derived pharmacokinetic parameter dependent on Clearance and Volume of Distribution (Vd).


                    0.693 * Vd
Half-life = ------------

                    Clearance

The above graph is based on a drug with a 12 hour half-life. The drug is being administered as a 12 hourly regiment. Change the Clearance and Vd using the sliders provided and see how the half-life changes. Pay particular attention to the changes in the time to reach steady state, the steady state concentrations, the magnitude of fluctuations in the concentrations and the extent of accumulation.

To view the single dose changes, click here.

To view multiple oral dose version, click here

To find out more, view the short video on "Determinants of Half-life".

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