EFFECT OF THE PRIMARY PHARMACOKINETIC PARAMETERS ON HALF-LIFE
Rate of Absorption :
Volume of Distribution :
The pharmacokinetic properties of any drug are best described through 4 primary parameters - bioavailability, rate of absorption, clearance and volume of distribution.
This interactive graph allows you to visualise the effects of changes to these parameters on the steady state pharmacokinetic profile of a particular drug with a half-life of 12 hours. The 4 parameters are allowed to vary geometrically from 0.5 to 2.0 times the original settings. Manipulate the values of the 4 parameters by adjusting the sliders provided, and note how the steady state pharmacokinetic profile of the drug changes. Consider how the safety-efficacy profile of the drug may vary within a population.
To practice how you can make dosage adjustments in the context of a multiple oral dose regimen, click here.