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EFFECT OF THE PRIMARY PHARMACOKINETIC PARAMETERS ON HALF-LIFE

    0.5 X

Bioavailability:

Rate of Absorption :

Volume of Distribution :

Clearance :

      0.5 X

2.0 X

2.0 X

     0.5 X

2.0 X

      0.25 X

1.0 X

The pharmacokinetic properties of any drug are best described through 4 primary parameters - bioavailability, rate of absorption, clearance and volume of distribution. 

This interactive graph allows you to visualise the effects of changes to these parameters on the steady state pharmacokinetic profile of a particular drug with a half-life of 12 hours. The 4 parameters are allowed to vary geometrically from 0.5 to 2.0 times the original settings. Manipulate the values of the 4 parameters by adjusting the sliders provided, and note how the steady state pharmacokinetic profile of the drug changes. Consider how the safety-efficacy profile of the drug may vary within a population.

To practice how you can make dosage adjustments in the context of a multiple oral dose regimen, click here.

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