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EFFECT OF CLEARANCE AND VOLUME OF DISTRIBUTION ON HALF-LIFE

Clearance:

Volume of distribution:

2.0 X

2.0 X

    0.5 X 

    0.5 X 

The Elimination Half-life is a derived pharmacokinetic parameter dependent on Clearance and Volume of Distribution (Vd).


                    0.693 * Vd
Half-life = ----------------

                    Clearance

The above graph is based on a drug with a 12 hour half-life. Change the Clearance and Vd using the sliders provided and see how the half-life changes. Notice any effects on the C0 and Area under the curve (AUC).

To explore these changes in the context of a multiple dose regiment, click here.

 

To find out more, view the short video on "Determinants of Half-life".

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