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Ms TP is young lady with complex psychomotor seizures.  She was placed on an oral regiment of an anti-convulsantThis drug has a half-life of about 10-22 hours but exhibits non-linear pharmacokinetics due largely to saturable drug metabolism. 

Current evidence suggests that to achieve adequate suppression of seizures, the trough concentrations should be above 0.01 mg/L. However, concentrations above 0.02 mg/L may be associated with increasing risks of drowsiness, suicidal ideation, and possible risks of arrhythmias.

Use the interactive graph to view a typical plasma concentration profile of this drug when given 12 hourly over a 19 day period.

Check out how long it may take to reach steady state concentrations.

Now use the sliders to change the rate of absorption, bioavailability, volume of distribution, as well as the Km and Vmax of the drug. Take note of how the plasma concentration profiles change.

Consider how the efficacy and safety of this drug may vary between patients.

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