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Vmax :

    0.5 X

Km :

Volume of distribution :

    0.5 X

    0.5 X

2.0 X

2.0 X

2.0 X

EFFECT OF VMAX, KM AND VOLUME OF DISTRIBUTION 

This interactive graph allows you to visualise the effects of changes to volume of distribution and the Michaelis Menten parameters of Km (empirically set as 0.018 mg/L) and Vmax on the "steady state" pharmacokinetic profile of a particular drug.

 

The parameters are allowed to vary geometrically from 0.5 to 2.0 times the original settings. Manipulate the values of the 4 parameters by adjusting the sliders provided, and note how the "steady state" pharmacokinetic profile of the drug changes. In this model, the half-life is not reported as it is concentration dependent.

 

Note how difficult it is to reach "steady-state" as the concentrations rise above the Km.
Consider how the safety-efficacy profile of the drug may vary within a population.

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