This interactive graph allows you to visualise the effects of changes to volume of distribution and the Michaelis Menten parameters of Km (empirically set as 0.018 mg/L) and Vmax on the "steady state" pharmacokinetic profile of a particular drug.

 

The parameters are allowed to vary geometrically from 0.5 to 2.0 times the original settings. Manipulate the values of the 4 parameters by adjusting the sliders provided, and note how the "steady state" pharmacokinetic profile of the drug changes. In this model, the half-life is not reported as it is concentration dependent.

 

Note how difficult it is to reach "steady-state" as the concentrations rise above the Km.
Consider how the safety-efficacy profile of the drug may vary within a population.

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