Mr Ismail, a 56 year old remisier, had recent symptoms of palpitations and giddiness. The cardiologist at the general hospital told him he had atrial fibrillation, and that he needed to be managed with an anticoagulant, warfarin.
Consider the following:
a] What would be the theraputic objective in the use of warfarin?
b] How would you determine the appropriate starting dose for Mdm Tan?
c] How long would it take for warfarin concentrations to reach steady state?
d] How would you monitor Mdm Tan for warfarin effects?
e] How would you optimize the warfarin maintenance dose?