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There was a time in Pharmacology, when acetylcholine was very topical, as were the effects of atropine. We studied the over-atropinization toxidrome by memorizing the idioms found in almost every textbookof Pharmacology : Hot as a hare, mad as a hatter, red as a beet, dry as a bone, blind as a bat..... Here is a contemporary remake of the toxidrome!
Step Approach Antihypertensive drugs
Adapted from the NICE Guidelines
Codeine dosing and CYP2D6
Since the analgesic effect of codeine depends on its metabolic conversion to morphine by CYP2D6. Its clinical efficacy and dosage requirements are going to be dependent on CYP2D6 genotype.
Types of drug interactions
A broad classification of the types of drug interactions. (Borrowed from the FDA site)
Classification of adverse events
These are the different types of adverse events classified according to the means by which they occur.
Clinical efficacy is the balance between the chance of producing a therapeutic benefit and the chance of occurence of a limiting toxicity. For every drug their is an optimal zone where these are maximally separated.
Know your drugs
Just as a good workman knows his tools, a good prescriber knows his drugs
Common sources of prescribing errors. Image taken from Ministry of Health publication "Medication Safety". https://www.moh.gov.sg/content/dam/moh_web/HPP/all_healthcare_professionals/Medication%20Safety.pdf
Error prone abbreviations
Common error prone prescribing abbreviations. Image taken from Ministry of Health publication "Medication Safety". https://www.moh.gov.sg/content/dam/moh_web/HPP/all_healthcare_professionals/Medication%20Safety.pdf
alcohol beverages - equivalents
An figure showing approximate equivalences between different common alcoholic beverages. The basic unit is a standard can (323mL) of beer (5% v/v).
Blood alcohol concentrations
Effect of the blood alcohol concentrations on cognitive degradation
Guide to good prescribing
7 reasons why you find it difficult to establish a good clinical concentration-response curve.
5 things to remember about the half-life
Definition of pharmacovigilance
Real evidence-based medicine
The conventional evidence-based medicine is flawed. Here is a proposal for a real approach towards EBM