This is a more advanced version of the previous interactive graph for dosage optimization. This interactive graph not only allows you to visualize the steady-state plasma concentration profile for a pre-selected pharmacokinetic profile, but allows you to randomly generate a fresh set of PK parameters based on the expected variability around the initial estimates.
1. Select the pharmacokinetic parameters as close as you can to a drug of interest. Confirm that the half-life is roughly what you intend it to be.
2. Define the maximum and minimum limits of the therapeutic range. (If you are not sure, just leave it blank. You can edit it later.)
3. Define the standard tablet size for this drug.
4. Then input your first dosage regimen, in terms of number of doses / dosing interval / number of tablets.
Sometimes, your first regimen gets the patient to the plasma concentration range required for optimal therapy. More often you will miss this range and will have to make dosage adjustments.
5. Amend the dosage regimen as often as you can by adding a new dosage regimen.
6. Hit the "Randomize" button. A fresh 'patient' will be generated with randomly generated PK parameter assumptions.
Recognise that it is not often easy to achieve the desired concentration range.
Note particularly how long the process of optimization might take as you work towards each steady state.
Consider how you can improve the efficiency of this process.
To check out the Non-Linear PK version of this app, click here
To insert drug interactions into the dose regimen, click here.